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These protective effects are attributed to resveratrol's pleiotropic mechanisms of action, which include its potent antioxidant capacity, suppression of proinflammatory signaling pathways such as NFB, and activation of sirtuin1 (SIRT1) a longevityassociated deacetylase implicated in neuronal survival and metabolic regulation

It was noteworthy that in fructose-induced diabetic rat model, treatment with GA increased expressions of Glut4, PPAR- and pAkt proteins, but not phosphorylated AMP-activated protein kinase (pAMPK) in the epithelial white adipose tissue, suggesting that GA attenuated insulin resistance through the Akt signalling pathway (Variya et al., 2020)

(2023, April 19)

The authors have declared a conflict of interest

Strengths: Based on a few small case series, this descriptive study provides some evidence of massive acetaminophen overdoses being treated successfully without hepatotoxicity with an increased final infusion of NAC

Zapp L, Slaga TJ, Zhao J, Lange M, Inventors