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And honestly, by the time I was in residency training, probably residency is the worst thing that could ever happen to your gut, isn't it

Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells

Antimalarials also help treat some autoimmune conditions (in which a persons immune system attacks their own body), such as rheumatoid arthritis and lupus

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Nat Rev Immunol 19: 433447, 2019.doi: 10.1038/s41577-019-0147-2

Practical fix: Let the vial and diluent equilibrate closer to room temperature before reconstitution, then refrigerate after the solution is fully clarified (when appropriate for your protocol)