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Thus, HDTCM is a very promising and viable research direction for developing therapeutic regimens that target multiple aspects of AD

These results confirm that IGF1R inhibition improves response to trastuzumab in HER2-positive breast cancer cells, and suggest that dual targeting of IGF1R and HER2 may improve response in HER2-positive tumors [28]
Sci Rep 9 , 2522 (2019)

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Further reading Bailey CS, Morgan JP

This may be an advantage since it could lead to a lower risk of systemic toxicity
