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Clinical trials involving over 900 human subjects across six randomized, double-blind, placebo-controlled studies confirmed the safety profile

For example, a study published in the American Journal of Clinical Nutrition found that B12 supplements reduced homocysteine levels and improved heart health in older adults

The NHS side-effects guidance for hydroxocobalamin, the form used in the UK, lists nausea, headache, dizziness and injection-site reactions as known effects that usually pass on their own

A low fermentable oligo-di-mono-saccharides and polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits

The British National Formulary (BNF) provides full clinical information on hydroxocobalamin

According to one report, 3% to 43% of older adults living independently may have low serum vitamin B12 levels, especially those with conditions such as atrophic gastritis or pernicious anaemia