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For instance, AKT kinase phosphorylates the Akt substrate of 160 kDa (AS160) which triggers the translocation of the glucose transporter GLUT4 to the cell surface, thus enhancing glucose uptake [50] (Fig

Intraneuronal absorption requires axonal transport and thus occurs over hours to days to reach target tissue throughout the brain

At the same time, collagen supports skin structure, making the brightening effects of glutathione more noticeable

MGO can also react with lysine and arginine residues with the formation of the crosslink 2-ammonio-6-((2-[(4-ammonio-5-oxido-5-oxopentyl)amino]-4-methyl-4,5-dihydro-1 H-imidazol-5-ylidene)amino)hexanoate (MODIC) [42]

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The delivery concept is plausible, and small human studies support biological delivery from tested formulations