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Another study compared crocin and saffron supplementation to a control group and noted a significant difference in the fasting glucose level ( p = 0.004), but no other metabolic markers ( Table 4 )

High-precision predictive models were used to demonstrate that CD8 + T OXPHOS cells serve as a critical immune population for evaluating the response to immune checkpoint inhibition (ICI) in melanoma patients [133]

Certain metallic cations, such as copper (Cu) and iron (Fe 2+/3+ ) may contribute significantly to the generation of ROS

The IRS proteins are commonly overexpressed in breast tumors, and in vitro knockdown of IRS expression limits breast tumor cell proliferation and invasive potential [124,173]

Consequently, the targeted regulation of iron ion homeostasis has emerged as an effective strategy for the prevention and treatment of numerous major diseases, with new clinical pharmacological agents being widely implemented [7]