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Astrocyte-associated axonal damage in pre-onset stages of experimental autoimmune encephalomyelitis

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Doses can be reduced or titration slowed

This allows it to pass through the intestinal wall and enter the bloodstream more effectively
And you do have to take breaks between use
The retarded leaching of nanoclusters can be attributed to their large size in comparison with molecular dyes and it is a clear advantage for imaging purposes as dye leaching decreases the fluorescence brightness of NPs and increases the background signal resulting in unfavorable imaging inefficiency/artifacts 50
