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total cumulative food intake in control and treated DIO mice was 28.11.2 g and 26.21.4 g, respectively (FIG

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The released DAG activates protein kinase C (PKC), while IP3 diffuses to the endoplasmic reticulum (ER) and binds to IP3 receptors on ligand-gated calcium channels on the surface of the ER, leading to a massive release of calcium ions into the cytosol [133]

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