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This section will provide an overview of adaptations in a wide array of neurochemical and neuromodulatory systems associated with alcohol dependence, with particular emphasis on their relationship to various signs and symptoms of the alcohol withdrawal syndrome, as well as their postulated role in underlying enhanced relapse susceptibility and perpetuation of excessive, unhealthy alcohol consumption

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Such local effects depend less on plasma bioavailability and more on the colonic delivery of bound phenolics and their microbial bioconversion products (Nicols Garca et al., 2021)

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If an IV is significantly associated with SZ related diseases or phenotypes (e.g., depression, anxiety disorder, affective disorder), it is identified as a potential confounder and excluded