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During the maturation stage, the biofilm forms a complex 3D structure with nutrient and waste channels, which is sustained by continued EPS production and regulated by quorum sensing

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The presence of WM changes in PD may reflect the observation that Lewy pathology in PD is much more widespread than was previously believed (Braak et al., 2003

Acta Biochim Biophys Sin (Shanghai) 2014;46:10411048