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Aged skin has been linked to reduced barrier function, dryness, and a higher risk of skin illness [108]

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[DOI] [PubMed] [Google Scholar] 55.Bajt ML, Knight TR, Lemasters JJ, Jaeschke H

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Collected tissues are performed as defined for termination of experiment and are snap frozen, fixed for histology or isolated for gene expression analysis

In this context, it seems that the available animal CIPN models are manifestations of gain in sensory functions which measure mainly allodynia, hyperalgesia and neurophysiological alterations in nerve function, whereas many patients, at least in the chronic phase of CIPN also report other symptoms, such as numbness, tingling and ongoing pain