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Many oral treatments have been studied, but results so far have been mixed.[5] Some consider the use of non-surgical approaches to be "controversial".[6] Vitamin E supplementation has been studied for decades, and some success has been reported in older trials, but those successes have not been reliably repeated in larger, newer studies.[7] A combination of Vitamin E and colchicine has shown some promise in delaying progression of the condition.[8] Newer agents targeting the basic mechanisms of inflammation have not yet been studied in larger clinical trials

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OR 1.18, 95% CI 0.463.02)