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When postprandial glucose and/or fasting blood glucose are sufficiently high, the polyol pathway (and OxS) will be activated in cells relying on GLUT1, e.g., endothelial cells [109,110]

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Neurochem Res 37:16811689 Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE, James SJ (2012) Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

Ferroptosis, a type of programmed cell death, first described in 2012 [6], is characterized by increased levels of redox-active iron and elevated lipid peroxidation

Martin-Bastida A, Ward RJ, Newbould R, et al

Cycling considerations for neuropathy protocols Long-term neuropathy protocols require thoughtful cycling to prevent receptor desensitization and maintain efficacy