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Though useful for accounting for study endpoint events in a rapidly fatal disease (i.e., death versus study completion versus trial withdrawal), combined outcomes suffer from issues with cross-trial validity and weighting the importance of relative contributions to outcome (death versus disease progression versus loss of follow-up) in creating the summed rank model [51]

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[DOI] [PubMed] [Google Scholar] 278.Denham J., OBrien B.J., Prestes P.R., Brown N.J., Charchar F.J