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Intriguingly, the MOXY study ( N = 24) revealed that while tcVNS significantly reduced migraine severity and frequency in female patients, salivary IL1 levels paradoxically increased after treatment, suggesting that VNS may provide symptomatic relief without resolving underlying neuroinflammatory processes, particularly in patients with aura, where cortical spreading depression continues to activate glial cells and perpetuate immune responses (Bostrm et al

& Peters, G

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10.3233/JAD-170020 509 ZhangW.DongX