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Both the J20 and modified J20 mice were aged to 1 yr of age, a time when OS and A deposition occurred in the J20 mouse brain, and showed in a mammalian species that no elevated OS in brain occurred in the Met631L-modified J20 mouse (119)

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doi: 10.1007/s12253-018-0417-5 64 WatsonJCStratakisCABryant-GreenwoodPKKochCAKirschnerLSNguyenTet al

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These amphipathic compounds are oriented so that their polar portions are exposed on the surface of the lipoprotein, thereby rendering the particle soluble in aqueous solution

Additionally, analyzing drug side effects offers insights into new drugtarget interactions, providing opportunities for drug re-purposing [45]