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iScience 26 (10), 107909

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Zhu adds, considering that keratinocytes are the major skin cell type in which HSV replicates in patients, the fact that acyclovir isnt all that potent at suppressing HSV in this cell type may explain why it isnt always effective in treating HSV flare-ups! Looking forward, the team is excited to follow up on some of their top antiviral candidates and keep developing their organoid models, whose utility in deciphering cell type-specific differences in antiviral effectiveness is now clear

5c), showcasing a substantial increase in genes such as ATF3 , LCN2 , CHD1 , CHP1 , NEAT1 , MUC1 , and P53 , whereas GALNT14 , ADAM23 , GPX4 , IDH , TGFB1 , PTGS2 , and SLC7A11 exhibited significant downregulation