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A further limitation is that our spectroscopic analysis was limited to the dorsal ACC and did not include more anterior/ventral portions of the medial prefrontal cortex

Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics Introduction Clearance is especially important for insuring appropriate long-term drug dosing with correct steady-state drug concentrations Clearance of a given drug is usually constant over the therapeutic concentration range because: Drug elimination systems are not saturated