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Meta-analysis was performed using a random-effects model, with 13 eventually meeting the inclusion criteria

Indeed, Luukkonen et al

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Additionally, ACEIs and ARBs directly counteract the toxic uremic effects of TMAO, which normally downregulates the expression of megalin, a crucial protein in renal albumin handling

Four patients (6.90%) were taking no ASMs, 11 patients (18.96%) were on monotherapy with one ASM, while 43 patients (74.14%) were on polytherapy of two or more ASMs