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In contrast, depletion of BCFAs triggered a gradual membrane depolarisation that was, in a mild form, already detectable after 30 min

The rate-limiting step in this process is the carnitine shuttle, specifically the CPT-I enzyme that attaches carnitine to long-chain fatty acids so they can cross the inner mitochondrial membrane

Avasimibe, a well-studied inhibitor of cholesterol esterification, has been found to effectively suppress tumor cell proliferation by targeting ACAT1 (SOAT1) to inhibit CE production

Kohlwein, S

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For instance, ATP-citrate lyase enzymatically cleaves citrate into acetyl-CoA, which leads to the carboxylation of acetyl-CoA and the formation of malonyl-CoA