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It can abstract hydrogen atoms from the deoxyribose sugar backbone, leading to strand breaks, or add to the double bonds of DNA bases, resulting in base modifications such as 8-hydroxydeoxyguanosine (8-OHdG) [28]

There was an old worry that nano particles might absorb through skin into the body but multiple studies (including on damaged, sunburned, and UV-irradiated skin) have shown that TD stays on the surface and the layer of dead skin cells on top of everything else
[DOI] [PubMed] [Google Scholar] 113.Walsh R.M., Saavedra J.R.A., Lentz G., Guerron A.D., Scheman J., Stevens T., Trucco M., Bottino R., Hatipoglu B
