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[DOI] [PubMed] [Google Scholar] 9.Chaudhuri K R, Odin P, Antonini A, et al

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This difficulty is a result of levodopas short half-life, a progressive narrowing of the therapeutic window, and major inter-patient and intra-patient variations in the doseresponse relationship

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Synthetic AT may be divided into two main categories: (i) those that have been primarily developed and synthetized as AT and (ii) compounds that primarily act via different mechanisms of action, while their AT properties were discovered later, which may contribute to their biological activity (as observed for some clinically used drugs, e.g., 4-aminosalicylic acid with inflammatory bowel disease (IBD))