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The recommended dose of pemetrexed for injection when administered with pembrolizumab and platinum chemotherapy for the initial treatment of metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered after pembrolizumab and prior to carboplatin or cisplatin on Day 1 of each 21-day cycle for 4 cycles

First-time users or those with sensitive constitutions are recommended to start at 50 mg daily for 12 weeks to observe body tolerance

Pemetrexed should not be used during pregnancy unless necessary, and breastfeeding should be avoided

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A 2024 study published in the Proceedings of the Nutrition Society found deficiency prevalence ranges from 5 to 52% in vegans and 6 to 14% in vegetarians, depending on supplement use