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Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in various bodily functions, including nerve function, red blood cell production, and DNA synthesis

Acknowledgements We would like to thank Bruce Wolffenbuttel and Andrew McCaddon for their advice and assistance of this perspective

Peptide synthesis, cleavage, purification, counterion composition, residual solvent profile, moisture content, peptide content, endotoxin status, storage history, and freeze-thaw exposure can all affect what is actually introduced into a cell culture or preclinical model system

The cell membrane is a thin layer that separates the interior of the cell from its surroundings and controls what enters and leaves the cell

Secondly, some people are not able to absorb vitamin b12 from the food they consume due to either some health conditions of the digestive system or because of some types of medicines which can reduce the absorption of vitamin b12

Specific populations requiring enhanced surveillance include: Patients on long-term metformin (test if deficiency is suspected