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Studies on rat colonocytes reported that the lower crypt cells are very much more sensitive towards hydrogen peroxide-induced damage than the differentiated cells located at the crypt surface (Pere, 2013)

Chen F, Wang H, Zhao J, et al
doi: 10.4088/JCP.v69n0401 [DOI] [PubMed] [Google Scholar] 100.Maayan L, Correll CU
The acids and caffeine travel across the gut wall, through the portal vein via the hemorrhoidal veins, and into the liver

Observed and predicted growth responses in prepubertal children with growth disorders: guidance of growth hormone treatment by empirical variables

PMID 20370935