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This is based on its ability to counteract ketamine and MK-801, NMDA receptor antagonists that model negative-like schizophrenia symptoms in rodents
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By rigorously identifying how cuprizone induces demyelination, we may find new parallels with human white matter diseases, such as MS, and be able to use this model more efficiently in preclinical studies
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[DOI] [PubMed] [Google Scholar] 696
