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However, ERT has lower therapeutic efficacy when started in advanced stages of Fabry disease 11,12

As summarized in Table 4, the therapeutic approaches can be broadly categorized into four mechanistic strategies: pigment fragmentation, thermal loosening of the scaffold structure, mechanical dispersion, and chemical degradation

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[DOI] [PubMed] [Google Scholar] 51.Li X., Qu Z.C., May J.M

Thus, MyD88 and TLR4 interact not directly but with the participation of TIRAP triggering the formation of a signaling complex