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Downregulation of Endogenous Peptide Production Introducing exogenous peptides may signal the body to decrease its own production of these compounds (a concept well-understood with hormonal therapies)

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Sun, L., Li, A., Hu, Y., Li, Y., Shang, L., & Zhang, L

(2) systemic mechanisms including gutbrain, erythrocytebrain, and kidneybrain axes
