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There are three stereoisomers for AST: a pair of enantiomers (3S,3S- and 3R,3R-AST) and an optically inactivemeso form (3R,3S AST [6] and geometric isomeric forms (Z and E isomers)) [6]

Recent studies have also highlighted the role of -syn propagation in spreading pathology across brain regions, further complicating the disease progression (Shin et al., 2023)

BBB dysfunction is characterized by increased permeability that allows blood-derived fluids and chemicals to enter the brain parenchyma, ultimately resulting in brain edema

Editorial: The metabolic challenges of immune cells in health and disease

"GlyNAC supplementation in old mice improves brain glutathione deficiency, oxidative stress, glucose uptake, mitochondrial dysfunction." J Gerontol A Biol Sci Med Sci

Transl Psychiatry 6(6):e844