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Fungal-targeted nanoconstructs (FTNx), using antisense oligonucleotides against FKS1 and CHS3 , can inhibit fungal cell wall synthesis genes, reduce fungal burden and improve survival in murine candidiasis models, exhibit broad-spectrum antifungal activity, including against clinical isolates of Candida auris ( Chung et al., 2025)

Moreover, estrogen is a restorative factor for several different autism genes and they revealed a conserved role for estrogen in inhibiting sonic Hedgehog signaling

doi: 10.1016/s0002-9440(10)63452-9

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