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We propose that dysbiosis promotes ferroptosis in ovarian granulosa cells through disrupted iron homeostasis, diminished production of protective microbial metabolites, and systemic inflammation, collectively contributing to the reproductive and metabolic disturbances in PCOS

doi: 10.1101/gad.8.12.1388 74 Rombol-CaldenteyB.Rueda-RomeroP.Iglesias-FernndezR.CarboneroP.Oate-SnchezL

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Plant Physiology, 148, 12011211

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Perspectives Despite these insights, existing research is largely limited by observational associations, a lack of global standardization in microbiome analysis, and significant individual heterogeneity in response to broad-spectrum interventions like FMT