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Studies have demonstrated alterations in catalase activity in individuals with CKD, hinting at a potential association between impaired antioxidant defenses and the advancement of renal damage [131]

Therefore, researches toward therapeutic approaches mainly focused on how to alleviate this event

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284 Dysregulated MT expression in ascending aortic smooth muscle cells from patients with bicuspid aortic valve (BAV) might lead to an insufficient response to oxidative stress, potentially triggering aneurysm formation

Its neuroprotective effects have been demonstrated in preclinical studies

Complementing these clinical findings, analyses of the gut microbiota have identified distinct microbial signatures associated with COVID-19