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This gene variation negatively impacts carnitine transport across the blood-brain barrier (in males and not females), preventing the synthesis of a carnitine precursor called trimethyllysine

Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z

Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart

There are several potential mechanisms whereby apoC-III can induce increased plasma triglycerides and accumulation of TRL remnant particles

J.DoraiT.PintoJ

[1] A common starting regimen in adults with normal renal and hepatic function is 1 mL intramuscularly once or twice weekly, titrated every four weeks according to biochemical markers such as fasting lipid panel, liver transaminases, and serum carnitine