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The VDR gene is placed on chromosome 12q12 and is expressed by many immune cells, especially dendritic cells

Besides their role in inflammation, these cytokines are detrimental to the processes of fertilization and embryo development: TNF- increases the free implants adhesions and their invasiveness through its effect on matrix metallo-proteinases (157) while TGF- hinders the local immune activity by inhibiting the natural killer cells which in turn impede the development of embryos (158)

This observation aligns well with the crucial ability of viruses to interact with host proteins (for example in the Potyviridae family), leading to the induction and support of virus infection in different hosts (Yang et al., 2021)

doi: 10.1203/01.PDR.0000079185.67878.72 19 KiharaMde HaanMWereEOGarrashiHHNevilleBGRNewtonCRJC

In an attempt to obviate such restrictive measures, emergency use authorization (EUA) of several different COVID-19 vaccines was issued by federal agencies around the world

Recknagel RO, Glende EA Jr, Dolak JA, Waller RL