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Neuroscience Letters, 570, 1027

the absolute necessity to focus

The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)

Huangfu Y

Most of these residues are conserved or replaced by similar amino acid residues in PfGrx or other enzymatically active glutaredoxins

Limited human clinical trial data Most evidence is preclinical and observational