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Integrating single-cell and experimental analyses uncover macrophage ferroptosis is a key event in the development of chronic obstructive pulmonary disease

At least in part, it was the practical fact of proximity

Despite this intrinsic temporal organization, current nutritional and metabolic guidelines rarely account for the cyclical nature of female physiology, highlighting a critical gap between endocrine biology and applied metabolic research

To further determine the role of IPA in the protection against IBD, groups of wild-type C57BL/6 J mice (WT B6) were administrated IPA through two distinct regiments according to previously published literatures: (1) daily oral gavaged with 200 mg/kg or 20 mg/kg IPA for 5 days, or (2) ad libitum access to drinking water containing 200 g/mL IPA for 14 days (approximately equivalent to 33 mg/kg/day), and then administered DSS for colitis induction (Supplementary Fig