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Description
Mechanistic relationships derived primarily from animal models, cellular studies, or indirect physiological inference are identified as mechanistically inferred (corresponding to dashed lines in Figure 1)
Many downstream target genes of NRF2, such as HO1, SLC7A11, FTH/L, and FPN, are related to the regulation of ferroptosis, suggesting NRF2 is a key negative regulator of ferroptosis [92]
MESNA is a chemoprotective agent used to prevent hemorrhagic cystitis caused by ifosfamide
The severity of lesions varies unpredictably in different parts of the nervous system, reflecting the random localization of the organism and the irregular distribution of inflammatory vascular change
AOD 9604 works through direct activation of fat cell receptors, bypassing appetite signaling entirely
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens
