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Both of those reductions are meaningful, triglycerides for insulin resistance and LDL for cardiac risk

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The insulinotropic functions of GLP-1 are mediated through interaction with GLP-1 receptors expressed on pancreatic cells

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As with all GLP-1 class medications, retatrutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome, and is not appropriate for patients with a history of pancreatitis

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The same active ingredient in Ozempic (semaglutide) is now licensed specifically for weight management under the brand name Wegovy at a higher dose

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Adopting a balanced diet rich in lean proteins, vegetables, and whole grains is recommended

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Similarly, large observational studies with robust methods for outcomes assessment (thyroid cancer and subtypes), analysis of confounders and comparisons between different agents in the GLP-1 RA class could help identify differences in associated risks for thyroid cancer

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