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The following mnemonic can classify the severity of eye disease: "NO SPECS": [28] Class 0: No signs or symptoms Class 1: Only signs (limited to upper lid retraction and stare, with or without lid lag) Class 2: Soft tissue involvement (oedema of conjunctivae and lids, conjunctival injection, etc.) Class 3: Proptosis Class 4: Extraocular muscle involvement (usually with diplopia) Class 5: Corneal involvement (primarily due to lagophthalmos) Class 6: Sight loss (due to optic nerve involvement) Typically, the natural history of TAO follows Rundle's curve, which describes a rapid worsening during an initial phase, peaking at maximum severity, and then improvement to a static plateau without, however, resolving back to a normal condition

In both systems reducing equivalents are provided by NADPH via dedicated oxidoreductase flavoenzymes

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