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In contrast to 23 (HA08), the pseudotripeptide 43 was not selective and the related ERAP1 and ERAP2 were inhibited as well showing IC50 values of 48 and 80 nM, respectively (Zervoudi et al., 2013)

The biologically plausible assumption that biologic materials would resist infection and perform better in contaminated fields has not consistently translated into superior clinical outcomes

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Takeaways: - Cryoneurolysis with current argon-based methods may not reliably reach low enough temperatures in large proximal nerves

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