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Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients discussion
This effect has also been studied in animals and in patients undergoing alcohol and opiate withdrawal treatment

ABC and SLC transporter expression and pot substrate characterization across the human CMEC/D3 blood-brain barrier cell line

Biochemistry, G Protein Coupled Receptors Treasure Island (FL: StatPearls (2023)
Balogh et al
10.1016/j.bbadis.2014.02.009 Biochim