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It's the gap between aligning a peptide protocol with the biology it was designed to exploit versus forcing it to work against circadian receptor rhythms that have been conserved across 200 million years of mammalian evolution

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In CIPN, calpains, as calcium-dependent proteases, have been shown to contribute to axonal degeneration [69]

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These results suggest that membrane protein activity can be regulated by fatty acid composition, with CFAs playing a significant role

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