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doi: 10.1177/0300060518777044 287 KocyigitAErelOGurelMSAvciSAktepeN

Download Table 4-1, DOCX file

They enable controlled release, site-specific targeting, enhanced therapeutic outcomes, and a reduced dosing frequency (101)

This means that the synapse mitochondria have additional functions at the nerve terminals, which may include Ca 2+ buffering directly affecting the firing probability of neurons [37, 38]

In order to enhance the antitumor activity of CD30-directed therapy, the cytotoxic drug monomethyl auristatin E (MMAE) was conjugated to a CD30-specific monoclonal antibody via a protease-cleavable dipeptide linker forming the ADC brentuximab vedotin (SGN-35) [41]

However, this same complexity can increase the risk of side effects or individual variability in response
