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Furthermore, multiple studies have demonstrated that collagen peptides can inhibit the expression of pro-inflammatory factors, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), IL-6, IL-8, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), in fibroblasts and keratinocytes, thereby mitigating inflammatory responses [32, 33]

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it is not, on its own, evidence sufficient to support a claim of life extension in humans absent independent randomized trials

The role of TLR2, TLR4 and CD36 in macrophage activation and foam cell formation in response to oxLDL in humans