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doi: 10.1007/s00240-024-01628-6 17 PradhanPJanaKGhoshSDebnathBRoutSKRaiVKet al

PLoS One 16:e0247060

For example, CRISPR-Cas9 editing to disrupt the BCL11A Erythroid Enhancer in HSPC was shown to reactivate production of fetal hemoglobin (HbF: 2 2 ) in place of adult hemoglobin (HbA: 2 2 ), and to overcome the transfusion-dependence in 91% (32/35) of -thalassemia patients in an international phase 3 trial comprising 20 (57%) TDT patients with severe genotypes 4 and in 2/2 pediatric 0 / 0 TDT patients in another recent clinical trial 5

Mol Asp Med
An essential vitamin yes but it often played second fiddle to vitamin C, D and Omega-3

doi: 10.1016/j.coi.2012.12.005
