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Indeed, chalcone-based compounds have been well documented to induce cell cycle arrest at G2/M phase through inhibition of microtubule polymerization [126,127]

The potential of glutathione as protectant is related to the pool size of glutathione, its redox state (GSH/GSSG ratio) and the activity of glutathione reductase

The GSH:GSSG ratio is one of the most observed measurements in modern cellular biology

Authors' contributions Taciana DalForno-Dini: Design and planning of the study