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(There are several studies involving animals, but not human subjects.) What research does show is that people who are overweight tend to be low in vitamin B12

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Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

Doctors might change the dose or how often you get shots based on what they see and lab tests

Appropriate amounts can vary per person based on many other factors

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