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The STEP trials reported nausea in approximately 44% of participants on semaglutide 2.4 mg versus 17.4% on placebo

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These treatments are extremely effective when combined with lifestyle changes but aren't one-size-fits-all

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A few sensible habits and the right bit of kit, and you can spend your headspace on the actual holiday instead of worrying about your medication
Support your skin microbiome and barrier if it is a bacterial issue, methods that help to rebalance or reduce bacteria levels on the skin may help