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Significant weight loss: In clinical trials, retatrutide has shown substantial weight loss compared to placebo

After adjustment for sex, BMI, hsCRP, and sCD163, semaglutide significantly decreased epigenetic aging: PCGrimAge (-3.1 years, P = 0.007), GrimAge V1 (-1.4 years, P = 0.02), GrimAge V2 (-2.3 years, P = 0.009), PhenoAge (-4.9 years, P = 0.004), and DunedinPACE (-0.09 units, 9 % slower pace, P = 0.01)

GLP-1 supplements: boosters (ColonBroom, Bioma, HUM) vs companion vitamins for Ozempic/Wegovy

Joint discomfort during GLP-1 therapy can stem from rapid weight loss, medication response, or individual metabolic factors

An average reduction of body weight by ~65 lbs in the high dose group from the baseline average of ~249 lbs is indeed impressive

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