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The reduced refolding by the chaperone is possibly due to the inability of these Syn variants to adopt the native tertiary inert state, causing prolonged chaperone engagement
The ability of IL-1 to induce chondrocyte catabolism [121] has been well known for a long time, but it is only recently that IL-1 has been shown to disrupt chondrocyte iron homeostasis [117] and trigger chondrocyte ferroptosis [22, 122]

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Neagu et al., 2023)

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The inflammatory milieu in IBD leads to enhanced ROS generation, causing DNA damage and subsequent 8-OHdG formation (186)
